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How to set variables during a project build in Python

I have some Python project, like a library. I have also two Azure DevOps environment feeds, NPRD and PROD for example. There are two different pipelines for build and post artifacts.

Now I need to define some different constants in my code for these envs, like URLS, end-points, etc. Maybe part of them I want to be secured. My built artifact (whl actually) will work on some user machine which I don't have access to and I can't define environment variables for my properties.

So how can I inject these values to the project during pipeline build? Is it possible?